1988 - A team of researchers headed by Prof. Yuichi
Mori of Waseda University, started working on developing non-biological
substrates for clinically usable cell culture
1992 - Dr Hiroshi Yoshioka et al standardize certain
Thermoreversible gelation polymer material and processing technology which
could yield certain advantagoeus results with clinically usable cells-
expansion and preservation with longer viability.
1995 - The toxicity studies related to the materials
and processing is cleared by the Japanese institutes and other authorities
and several universities and laboratories start using the technology in
their experiments ((St.
Marianna University- Prof. S. Kubota, Tokyo University- Dr. Hishikawa,
Institute of Infectious Diseases- Dr. Suzuki, Jikei University Dr.
Murayama, Harvard Medical School- Dr. Koji Kojima ).
1998 - Mr Morozumi Yoshio, then director of Kyowa
Medical Corporation visits India and interacts with several institutes and
private business organizations to know about the Indian health care
1999 - Dr Samuel JK Abraham, starts interacting with
Prof. Mori, Dr Noishiki et al for the clinical application of a Ultra-fine
filament polyester based vascular graft and its value addition with
2000 - In India, a private organization is
registered under the name "Nichi-In Bio Sciences Pvt Ltd" with Japanese
equity participation for taking the Japanese technology to several health
2002 - An informal collaboration starts with M/S
Vision Research Foundation, Sankara nethralaya starts for research using
the technology and materials handed over by M/S Nichi-In Bio Sciences Pvt
2004 - A formal agreement with Sankara Nethralaya
was signed and a research on Corneal limbal epithelial stem cells was